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Xin Zou, Ke Chen, Jiawei Zou, Peiyi Han, Jie Hao, Zeguang Han
《医学前沿(英文)》 页码 185-192 doi: 10.1007/s11684-020-0754-0
It has been known that, the novel coronavirus, 2019-nCoV, which is considered similar to SARS-CoV and originated from Wuhan (China), invades human cells via the receptor angiotensin converting enzyme II (ACE2). Moreover, lung cells that have ACE2 expression may be the main target cells during 2019-nCoV infection. However, some patients also exhibit non-respiratory symptoms, such as kidney failure, implying that 2019-nCoV could also invade other organs. To construct a risk map of different human organs, we analyzed the single-cell RNA sequencing (scRNA-seq) datasets derived from major human physiological systems, including the respiratory, cardiovascular, digestive, and urinary systems. Through scRNA-seq data analyses, we identified the organs at risk, such as lung, heart, esophagus, kidney, bladder, and ileum, and located specific cell types (i.e., type II alveolar cells (AT2), myocardial cells, proximal tubule cells of the kidney, ileum and esophagus epithelial cells, and bladder urothelial cells), which are vulnerable to 2019-nCoV infection. Based on the findings, we constructed a risk map indicating the vulnerability of different organs to 2019-nCoV infection. This study may provide potential clues for further investigation of the pathogenesis and route of 2019-nCoV infection.
福田敏男:Bio Cell Analysis and Assembly by Micro and Nano Robotic Technology(2019年8月25日)
福田敏男(院士)
2021年01月20日
关键词: 采油工程
《医学前沿(英文)》 doi: 10.1007/s11684-023-1017-7
关键词: single-cell RNA-seq glioma radial glia primitive oligodendrocyte precursor cell immune escape
Hongqi Wang, Ruhan Jiang, Dekang Kong, Zili Liu, Xiaoxiong Wu, Jie Xu, Yi Li
《环境科学与工程前沿(英文)》 2020年 第14卷 第1期 doi: 10.1007/s11783-019-1188-2
关键词: Polycyclic aromatic hydrocarbons Transmembrane transport Adsorption and uptake of hydrocarbons Proteomics Functional regulation of membrane protein Single cell analysis technology
徐健, 马波, 苏晓泉, 黄适, 徐欣, 周学东, 黄巍, Rob Knight
《工程(英文)》 2017年 第3卷 第1期 页码 66-70 doi: 10.1016/J.ENG.2017.01.020
方法学创新一直是微生物组学研究的核心驱动力。我们认为在未来五到十年,微生物组的方法学体系在研究理念与技术平台方面将发生三大变革:①从监测菌群“结构”变化向监测菌群“功能/状态”变化的变革;②从细胞“群体”分析精度向细胞“个体”分析精度的转变;③从“数据分析”向“数据科学”的跨越。在这里我们针对实现上述三大方法学变革需要克服的关键科学或技术挑战,重点介绍了部分中国微生物组分析方法学研究团队及其国际合作伙伴的最新工作进展。我们相信中国微生物组计划应把握住当前这一重要机遇,通过在微生物组分析方法学前沿开展富有雄心、远见、创意与竞争力的交叉合作研究,为国际微生物组计划贡献一系列“中国制造”的新方法、新工具和新仪器。
Computer-Aided Design System for CP Single-Screw Compressor
SHEN Jing-feng, YAO Fu-sheng
《机械工程前沿(英文)》 2006年 第1卷 第1期 页码 21-25 doi: 10.1007/s11465-005-0018-3
To design various optimum parameters and simulate the working process of CP single-screw compressor, the Computer-Aided Design (CAD) system for the CP single-screw compressor has been established. A new method based on computer graphics technology, database technology, object-oriented programming technology, and visual simulation technology has been adopted in this CAD system. The system has integrated solid modeling function with parameterization design function and animator simulation function based on analyzing the working principle of the CP single-screw compressor. The experimental results show that the CAD system for the CP single-screw compressor is practical and feasible.
关键词: CP single-screw database technology simulation technology programming technology animator simulation
Distinct mononuclear diploid cardiac subpopulation with minimal cell–cell communications persists in
《医学前沿(英文)》 页码 939-956 doi: 10.1007/s11684-023-0987-9
关键词: mononuclear diploid cardiomyocytes cell–cell communication cardiac fibroblast single-cell RNA sequencing cardiac regeneration
《医学前沿(英文)》 2022年 第16卷 第2期 页码 251-262 doi: 10.1007/s11684-021-0915-9
关键词: scRNA-seq intracellular pathogen microbe COVID-19 SARS-CoV-2
《机械工程前沿(英文)》 2022年 第17卷 第3期 doi: 10.1007/s11465-022-0695-1
关键词: translational parallel mechanism single loop multiple driving system workspace analysis singularity
null
《医学前沿(英文)》 2015年 第9卷 第4期 页码 468-477 doi: 10.1007/s11684-015-0419-6
Mature T-cell lymphoid malignancies comprise a group of heterogeneous diseases that vary in clinicopathological features, biological behavior, treatment response, and prognosis. Bone marrow (BM) infiltration is more commonly present in mature T-cell lymphoid malignancies compared with their B-cell counterparts and hence important for differential diagnosis. In this study, clinical characteristics and prognostic factors were analyzed in 225 patients with mature T-cell lymphoid malignancies treated in a single institution. These included 29 cases of T-cell lymphoproliferative disorders (T-LPD, all with BM infiltration) and 196 cases of T-/natural-killer-cell lymphoma (T/NKCL, 56 with BM infiltration and 140 without BM infiltration). The estimated 5-year overall survival (OS) rates of T-LPD and T/NKCL were 96.6% and 37.3%, respectively. T-LPD patients were less likely to exhibit poor performance status, advanced disease stage, presence of B symptoms, or abnormal level of serum β-2 microglobulin. With similar pathological characteristics, T/NKCL patients with BM infiltration showed significantly lower response rates and shorter OS than those without BM infiltration (P = 0.0264 and P<0.0001, respectively). Multivariate analysis indicated that poor performance status, advanced disease stage, elevated serum lactate dehydrogenase level, and BM involvement were independent unfavorable prognostic factors. The Glasgow Prognostic Score may be more efficient than the International Prognostic Index in predicting disease outcome in T/NKCL. In conclusion, clinical characteristics may be useful in more effectively stratifying patients with mature T-cell lymphoid malignancies.
关键词: mature T-cell lymphoid malignancies clonal T-cell population bone marrow infiltration prognostic factors
《结构与土木工程前沿(英文)》 2023年 第17卷 第2期 页码 224-237 doi: 10.1007/s11709-022-0914-1
关键词: single batter pile skew horizontal load model test finite-element analysis empirical design method
Ying Huo, Peng Yuan, Qingyuan Qin, Zhiqiang Yan, Liying Yan, Ping Liu, Rong Li, Jie Yan, Jie Qiao
《医学前沿(英文)》 2021年 第15卷 第1期 页码 144-154 doi: 10.1007/s11684-020-0792-7
关键词: human metaphase II oocyte vitrification cryostorage duration single-cell RNA-Seq lncRNA
A cytoprotective graphene oxide-polyelectrolytes nanoshell for single-cell encapsulation
Luanying He, Yulin Chang, Junhao Zhu, Ying Bi, Wenlin An, Yiyang Dong, Jia-Hui Liu, Shihui Wang
《化学科学与工程前沿(英文)》 2021年 第15卷 第2期 页码 410-420 doi: 10.1007/s11705-020-1950-9
Ling Wang, Lining Wang, Xing Fan, Wei Tang, Jiong Hu
《医学前沿(英文)》 2021年 第15卷 第1期 页码 108-115 doi: 10.1007/s11684-019-0730-8
关键词: post-transplantation cyclophosphamide allogeneic hematopoietic stem cell transplantation lymphoid malignancies
标题 作者 时间 类型 操作
Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potential risk of different
Xin Zou, Ke Chen, Jiawei Zou, Peiyi Han, Jie Hao, Zeguang Han
期刊论文
福田敏男:Bio Cell Analysis and Assembly by Micro and Nano Robotic Technology(2019年8月25日)
福田敏男(院士)
2021年01月20日
会议视频
Distinct immune escape and microenvironment between RG-like and pri-OPC-like glioma revealed by single-cellRNA-seq analysis
期刊论文
Transmembrane transport of polycyclic aromatic hydrocarbons by bacteria and functional regulation of membrane proteins
Hongqi Wang, Ruhan Jiang, Dekang Kong, Zili Liu, Xiaoxiong Wu, Jie Xu, Yi Li
期刊论文
Distinct mononuclear diploid cardiac subpopulation with minimal cell–cell communications persists in
期刊论文
PathogenTrack and Yeskit: tools for identifying intracellular pathogens from single-cell RNA-sequencing
期刊论文
Design and analysis of partially decoupled translational parallel mechanisms with single-loop structures
期刊论文
Clinical characteristics and prognostic factors of patients with mature T-cell lymphoid malignancies:a single-institution study of 225 cases
null
期刊论文
Numerical analysis of bearing behaviors of single batter piles under horizontal loads in various directions
期刊论文
Effects of vitrification and cryostorage duration on single-cell RNA-Seq profiling of vitrified-thawed
Ying Huo, Peng Yuan, Qingyuan Qin, Zhiqiang Yan, Liying Yan, Ping Liu, Rong Li, Jie Yan, Jie Qiao
期刊论文
A cytoprotective graphene oxide-polyelectrolytes nanoshell for single-cell encapsulation
Luanying He, Yulin Chang, Junhao Zhu, Ying Bi, Wenlin An, Yiyang Dong, Jia-Hui Liu, Shihui Wang
期刊论文